The most important characteristic of amines governing their reactivity is their nucleophilicity. Amines reach with alkyl halides by means of nucleophilic substitution. They react with aldehydes or ketones via nucleophilic addition, and amines react with carboxylic acid derivatives via acyl substitution.

Amines are the most generally significant bases in biochemistry. They are also often involved as nucleophiles in biochemical processes.
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