If both the enolate and the aldehyde both contain pre-existing chirality, then the outcome of the double stereodifferentiating aldol reaction may be predicted using a merged stereochemical model that takes into account the enolate facial bias, enolate geometry, and aldehyde facial bias. The figure shows several examples of the application of this model.

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If both the enolate and the aldehyde both contain pre-existing chirality, then the outcome of the double stereodifferentiating aldol reaction may be predicted using a merged stereochemical model that takes into account the enolate facial bias, enolate geometry, and aldehyde facial bias. The figure shows several examples of the application of this model.