Substrate, bound substrate, and transition state conformations of lysozyme. The substrate, on binding, is distorted from the typical 'chair' hexose ring into the 'sofa' conformation, which is similar in shape to the transition state.

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Substrate, bound substrate, and transition state conformations of lysozyme. The substrate, on binding, is distorted from the typical 'chair' hexose ring into the 'sofa' conformation, which is similar in shape to the transition state.